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A sleep epidemic is facing the U.S. That’s not hyperbole: the CDC itself has labeled sleep deprivation a public health issue. Over a third of Americans aren’t getting enough sleep on a regular basis, and insomnia is on the rise.
Many Americans turn to sleep aids to relieve their insomnia. Numbers vary, but up to a quarter of Americans use some sort of sleep aid to help them fall asleep, according to the American Academy of Sleep Medicine. Between 6 to 12% of Americans use over-the-counter sleep aids specifically.
Because they come with a non-habit forming label and are sold over-the-counter, many people believe sleep aids are safe. Generally, they are, but only when used properly and on a short-term basis.
This guide will tell you everything you need to know about over-the-counter sleep aids, so you can make an informed decision the next time you have a sleepless night. We’ll also share our top picks for the best OTC sleep aids.
Over the counter sleep aids are designed for short-term use to help a person fall asleep.
Active Ingredients: Doxylamine Succinate or Diphenhydramine HCI
Dosage Instructions: Take one dose 30 minutes before bed.
Common Side Effects: Daytime drowsiness, dizziness or loss of coordination, blurred vision, dry mouth, constipation or upset stomach.
Price: $2 to $12, depending on count.
Safe Use Tips:
Do not combine with other sedative drugs.
Don’t drink or drive.
Start with the lowest dose.
Read the label carefully.
Use on a short-term basis, for up to 2 weeks.
Use before bed when you have time to sleep for at least 7 hours.
Avoid using OTC sleep aids if you are pregnant, breastfeeding, under age 12, or have another health condition (particularly a breathing disorder, glaucoma, urinary retention or an enlarged prostate, or Alzheimer’s).
Unlike prescription sleep aids, which require you to get a prescription from a doctor, OTC sleep aids can be purchased over-the-counter at your local drugstore.
Antihistamines are the only FDA-approved over-the-counter sleep medication. These sleep aids work by reducing the amount of histamines released into your bloodstream. Your body responds by feeling sleepy.
If you abuse over-the-counter sleep aids or take them for longer than a few days, your body may develop a tolerance to their sedative effects. As a result, they may eventually stop working as well, and you won’t fall asleep as easily.
The two main types of over-the-counter sleep aids you’ll encounter are diphenhydramine and doxylamine succinate. Both of these are sedating antihistamines.
Diphenhydramine is the main ingredient in OTC sleep aids like Unisom SleepGels and ZzzQuil, pain reliever/sleep aid medications like Aleve PM or Tylenol PM, and allergy relief medications like Benadryl.
Doxylamine succinate is the main ingredient in OTC sleep aids like Unisom SleepTabs and Kirkland Signature Sleep Aid.
Types of Sleep Aids: OTC vs. Natural vs. Prescription Drugs
Sleep aids fall into three main categories: over-the-counter, natural or herbal supplements, and prescription drugs.
Over-the-counter sleep aids are typically antihistamines. They’re designed to address short-term sleeplessness, not insomnia. Their side effects are typically mild, such as drowsiness the next day, which is why they can be sold over the counter. However, there are instances where these can be unsafe for people.
Natural sleep aids include dietary and herbal supplements containing ingredients like melatonin, valerian, or chamomile. Like over-the-counter sleep aids, these have not proven effective as a treatment for long-term insomnia. Natural sleep aids may come in the form of herbal teas, pills, or ointments.
Prescription drugs target different parts of the brain to induce sleep. Doxepin (Silenor) blocks histamine receptors, enabling the person to stay asleep throughout the night, while zolpidem (Ambien and others) help induce sleep by activating the neurotransmitter GABA and binding it to GABA receptors. Prescription drugs require a prescription because these are designed to help treat chronic insomnia and other sleep disorders like sleepwalking. These drugs are stronger and have stronger side effects which can cause extreme drowsiness, sleep-driving, or more if not taken as prescribed.
Generally, sleep aids are considered safe for short-term use. It is when people misuse sleep aids, particularly by using them on a long-term basis, that they become dangerous.
Unfortunately, this describes a significant number of the people who use sleep aids. Just under 20% of people take sleep aids to help them fall asleep every night. Among older adults, that number is even higher: over a third of adults age 65-80 regularly rely on some form of OTC, prescription, or natural sleep aid on a daily basis.
Because they are not addictive the same way other drugs are, the FDA allows the “non-habit forming” label to be used for OTC sleep aids – but that’s assuming safe use. Given the frequency with which people don’t use sleep aids safely, and the billion-dollar industry they’ve become, researchers are concerned about the risk for dependence.
For example, one 2008 study of rats found that diphenhydramine and cocaine – a highly addictive substance – had a similar effect on dopamine release in the brain.
OTC sleep aids are not designed to be a long-term solution for insomnia. "
When people take higher than the recommended dose, use them on a long-term basis, or otherwise don’t follow safe use guidelines, their risk of dependence and other adverse outcomes may increase.
When should you use sleep aids?
Sleep aids should be used on a short-term basis to relieve difficulty falling asleep during a period of two weeks or less. Good examples of this may include:
Using sleep aids to manage jet lag after traveling across time zones.
Using sleep aids as advised by a doctor to facilitate sleep while recovering from a medical procedure.
Using sleep aids on another, as-needed, short-term basis to help a person fall asleep.
It is important to use sleep aids sparingly and on a temporary basis - for both your immediate sleep needs and your long-term health. "
Sleep aids are designed to help you fall asleep when there is a temporary situation causing difficulty sleeping. They are not designed to cure chronic insomnia.
Sleep aids work because they are highly effective, but that’s also what can make them potentially addictive. If a person comes to rely on the sleep aid to help them fall asleep, instead of adjusting their lifestyle or behavior, or addressing the underlying health conditions that contribute to their insomnia, they’ll always have trouble sleeping without the sleep aid. If sleep aids are used as a long-term solution, the underlying issue is never resolved. Not only will their insomnia persist, but the person may begin to experience other unfortunate side effects as well.
Instead of applying a short-term fix to a long-term problem, the healthier, more sustainable approach is to implement lifestyle and behavioral changes for better sleep. Just a few lifestyle changes can relieve insomnia for a majority of people. We’ll review these in a later section of the article.
Side effects of over-the-counter sleep aids
Even when used on a short-term basis, sleep aids, like most drugs, may cause side effects that make them unsafe for some people. Over-the-counter sleep aids do have fewer side effects than prescription sleep aids, but they are still important to be aware of.
Common side effects of OTC sleep aids
Moderate or severe daytime drowsiness (this “hangover effect” is the most common side effect)
Feelings of dizziness or being off-balanced
Blurred vision or dry eyes
Constipation or urinary retention
Dry mouth, nose or throat
When you should avoid OTC sleep aids
There are instances where over-the-counter sleep aids pose a stronger risk for certain groups of people. If you fall into one of the following categories, you should probably avoid sleep aids altogether or at the very least consult your doctor first before using them.
Generally, most OTC sleep aids should be avoided by children younger than 12 years old. Depending on their age, children have different physiologies than we do as adults. Taking the same dosage or medication as recommended for adults can be very unsafe for children. Doctors even recommend that the pediatric dosage be adjusted for natural sleep aids like melatonin.
Also, there are a variety of insomnia triggers that may be unique to a child’s experience, such as a fear of the dark, nightmares, sleepwalking, or trouble at school.
If your child is having trouble sleeping, our Parents Guide to Healthy Sleep offers behavioral strategies you can try to help them sleep better. You may also speak to their pediatrician about their sleep issues as well.
Pregnant or breastfeeding
During pregnancy, a woman’s body goes through extreme changes that can make restful sleep difficult to achieve. Unfortunately, sleeping well is important to a healthy pregnancy. But the hormonal and physical changes associated with pregnancy can increase the mother’s risk of suffering adverse side effects from taking over-the-counter sleep medication.
Consult with your doctor before using natural sleep aids, too. The body’s production of melatonin naturally increases at 24 and 32 weeks of pregnancy, and scientists have not yet determined whether melatonin is safe for pregnant mothers. One study of rats found that melatonin negatively impacted the size, health, and mortality rate of their pups.
Our guide to Pregnancy and Sleep offers safe sleep products and behavioral tips you can try to help you sleep better.
Sick with an illness
If you are temporarily sick and are taking other over-the-counter medications to relieve your symptoms, they may negatively interact with a sleep aid. Since most over-the-counter sleep aids are antihistamines, and you are also taking antihistamines for a cold or allergy, you may inadvertently overdose and cause adverse side effects.
It is best to avoid taking sleep aids in addition to other medication when you’re sick, unless your doctor has given you the go-ahead. Instead, try switching to “nighttime” versions of your medication at night to help you fall asleep.
Taking other medications
If you have a chronic condition and regularly take other medications to manage your system, you’ll want to consult with your doctor before introducing an over-the-counter sleep aid into the mix. You just want to be sure that the ingredients don’t interact negatively with each other.
Chronic conditions that pose a particular risk include sleep apnea, asthma or another chronic lung disease, glaucoma, severe liver disease, Alzheimer’s, or urinary retention or problems due to an enlarged prostate.
Your doctor may be able to suggest a healthy sleep aid option for you that won’t affect your medication, or you may rely on the behavioral methods below to help you fall asleep better.
Children, pregnant or breastfeeding women, and people who are taking medication for chronic conditions or illness should avoid over-the-counter sleep aids. "
The Best Over-the-Counter Sleep Aids
Kirkland Signature Sleep Aid
Here’s what you need to know:
Active Ingredient: Doxylamine Succinate 25 mg
Count: 96 tablets
Dose: Take 1 tablet orally 30 minutes before bed
Side Effects: Drowsiness, dizziness, dry mouth, blurred vision, constipation.
If you don’t fall into a risk category and you’re going to try over-the-counter sleep aids, consider the following advice for safe use.
Do not combine sleep aids with other sedative drugs. If you are taking another sedative medication, you may run into overdose territory.
Don’t drink. Likewise, do not combine sleep aids with alcohol. This is extremely dangerous. Alcohol is a sedative and a depressant that induces drowsiness, and it also lowers your sleep quality.
Don’t drive.You should take a sleep aid right before you plan to go to bed. Do not take a sleep aid if you plan to operate a car afterwards, especially if this is your first time taking the sleep aid and you don’t know how it will affect you.
Use directly before bed, only when you have time for a full night of sleep. The right time to take a sleep aid is before bed, at a time when you have room to sleep for at least 7 hours. If you take a sleep aid later than that, you may feel extremely drowsy the next day.
Start with the lowest dose. You are not sure how the sleep aid will interact with your system. When you first take a sleep aid, and for the first few times after that, start with the lowest dose. Do not double up during the night as this can make you extremely tired the next day.
Read the label and package insert carefully. The label will provide you with detailed information on potential side effects you can expect, guidelines for the recommended dosage and how to take it properly, and any medications, health conditions, food or beverages that need to be avoided for safe use.
Plan to use this as a short-term sleep aid. A sleep aid should be relied on as a temporary solution for jet lag or other sleep emergencies. Frequent use can lead to dependency and dangerous side effects.
Talk to your doctor if you have any questions. If you have any questions at all, do not hesitate to speak to your doctor or pharmacist about the right sleep aid to use, and any recommendations they have for improving your sleep. Make sure to inform them of any other medication you’re currently taking for other health conditions. Ask questions about how to increase, taper off, or stop using the sleep aid.
Behavioral techniques to improve sleep
For a long-term fix to your insomnia, healthcare professionals, sleep experts, and researchers alike recommend employing behavioral techniques. Studies consistently show that lifestyle modifications and behavior changes can solve a multitude of sleep problems for most people.
Review the following list of research-backed sleep tips. Consider how you can incorporate more of these into your life so you don’t need to rely on over-the-counter sleep aids.
Keep your bedroom cool, dark, and quiet. The optimal temperature for sleep is in the low to mid-60 degrees Fahrenheit. To facilitate deep, restful sleep, set your bedroom thermostat to a cool temperature, and make your bedroom as dark and as quiet as possible.
Follow a consistent sleep schedule. Go to bed and wake up at the same time everyday. Ensure there’s room for you to get at least 7 hours of sleep between those times.
Reserve your bedroom for sleep and sex only. The goal is to train your mind to view your bedroom as a location for sleep and restfulness, not work or leisure.
Practice relaxation techniques before bed.Deep breathing exercises, progressive muscle relaxation, meditation and visualization can all physically relax your body and induce sleep.
Develop and follow a calming bedtime routine. Each night, complete the same set of activities in the 30 to 60 minutes before you go to bed. These may include your relaxation techniques, along with activities like brushing your teeth or taking a warm bath. Whatever activities you choose, they should be relaxing and help prepare you for sleep.
Avoid using electronics at least 1 hour before bed. One thing your bedtime routine should not include is watching TV or checking email. The blue light in electronic devices is perceived especially strongly by the receptors in your brain, and interpreted as sunlight. Your brain responds by keeping you awake, instead of allowing you to relax and fall asleep.
Don’t eat or drink heavily at night. Heavy meals and alcohol consumption can cause indigestion and disrupt the quality of your sleep. Instead, hydrate with water and snack on light, sleep-promoting foods.
Exercise during the day. Exercise physically tires your body out, and it also helps reinforce your natural circadian rhythms. By exercising during the day, you raise your body temperature. As your temperature goes down, your brain begins its natural melatonin production later in the evening, enabling you to fall asleep by bedtime.
Get natural light during the day. Speaking of your circadian rhythms, natural sunlight gives you an energy boost during the day. When the sun lowers in the afternoon, your brain recognizes the change and begins to prepare you for sleep.
Try cognitive-behavioral therapy for insomnia (CBT-I). If you are still having trouble sleeping, CBT-I is the most effective treatment for insomnia. Over a period of weeks to months, a specially trained therapist works with you to help you understand the thoughts and behaviors you engage in that inhibit healthy sleep, and then provides you with exercises to change them.
Articles from Tuck:
Learn more about the potential causes behind your insomnia, and your treatment options in our in-depth Insomnia resource page.
The Medications for Insomnia page on Drugs.com lists side effects, risk factors, dosage recommendations and more for prescription sleeping pills and over-the counter sleep aids. The site also displays customer reviews for each drug.
The FDA lists comprehensive information on all drugs, including over-the-counter sleep aids. You can find information on side effects, dosage guidelines, safety precautions and more using their Drug Finder tool.
The Dietary Supplement Label Database, operated by the National Institutes of Health, provides information on ingredients, side effects, and dosage recommendations for a variety of OTC sleep aid supplements.
MedlinePlus is another database, operated by the U.S. Department of Health and Human Services, which provides information on side effects, dosage guidelines, and drug interactions. Prescription drugs, over-the counter medicines, and herbs and supplements are included in the database.